Next, we estimated SNP effects on the components of the gSEM. The tolerance setting for matrix inversion was set to a relatively liberal value (1e-50) to allow model fitting to proceed. The ‘standard’ option was selected to implement Genomic Control. SNPs were restricted to those appearing in both the meta-analyses and the 1000 Genomes reference panel and had a MAF > .01 in the reference panel. The total number of SNPs included in the analysis was 6,707,536. The average of SNP-specific sample sizes for adolescence, early adulthood, and adulthood were 8,869.29, 9,647.64, and 9,894.18, respectively. The effective sample size for the common factor, calculated using the formula defined in Mallard et al. (2022a), was 12,180.07.
