maps within STAT3 (signal transducers and activator of transcription, member 3). On the X chromosome rs2807261 (P=1.3×10-7) maps 50-kb from the gene CD40LG (CD40 ligand—previously known as TNF superfamily, member 5), implicated in the regulation of B-cell proliferation, adhesion and immunoglobulin class switching71. As described in the section on T1D, a modest association between CD and SNPs in the vicinity of the PTPN11 gene on chromosome 12q24 (P=1.5×10-3) probably reflects a locus influencing general autoimmune predisposition.
