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Chunk #14 — Results — Polygenicity

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Charting the Landscape of Genetic Overlap Between Mental Disorders and Related Traits Beyond Genetic Correlation.
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ADHD was the least polygenic mental disorder (N=5,600 ‘causal’ variants explaining 90% of ADHD’s h2SNP, SD=400), followed by BIP (n=8,600, sd=200) and schizophrenia (n=9,600, sd=200). Intelligence, neuroticism, and subjective well-being were estimated to be associated with 11,200–12,500 variants at 90% h2SNP, while EDU (n=13,200, sd=300) and MD (n=14,500, sd=700) were most polygenic (fig. 2). Height was less polygenic (n=4,000, sd=100). This pattern of polygenicity was distinct from h2SNP estimates (fig. 2). Heritability, discoverability and power analyses are described in supplementary results, supplementary table 4 and supplementary fig. 2.