2002) for a review). Y1, Y2, and Y5 receptors, and receptor mRNA are found in the amygdala, and each of these receptor subtypes has been implicated in anxiety (Kask et al. 2002). Y2 receptors are thought to act presynaptically as auto-receptors providing negative feedback to NPYergic nerve terminals, whereas Y1 receptors appear to act postsynaptically (Kask et al. 2002; Wolak et al. 2003).
