ganglia, cingulate cortex, amygdala, and hippocampus (Witkin et al., 2005), and autoradiographic studies have demonstrated high densities of CB-1 receptors in the frontal cortex, reported to be nearly twice as high as those found in the posterior occipital cortex (Herkenham et al., 1990), and of higher density in these areas in humans relative to rat or monkey brain (Pertwee, 1997). Given the association between CB-1 receptors and mood, the current study is aimed at identifying the relationship between affective processing and activation within specific brain regions in chronic heavy marijuana smokers.
