We searched for similar haplogroups in the other HapMap populations (the combined JPT/CHB and YRI). The “INT1” haplogroup that includes the intron 1 variants of block 4 accounts for ~4% in these populations. In contrast, the “118G” haplogroup has a very different pattern. In concordance with the 118G allele frequency, the 118G haplogroup that includes the 5′ variants of block 1, is very frequent in the Asian population and can be divided into two subgroups, the major one (28%) includes the variants in block 1, similar to European Americans, and the second (14%) has other combinations (data not shown). The 118G allele was not found in the African sample but a similar haplogroup with block 1 variants (without the 118G variant allele) was represented by 7.5% of the haplotypes. Interestingly, there was a significant representation (~30%) of the block 3 haplogroup, with variants at the proximal 5′ region, in the African sample, in contrast to the low frequency in the Asian and Caucasian samples.
