at least twice. By contrast, the number of calls (21 in total) for the 10 extreme obesity GSV loci represented a 30% lower frequency than in the original report (29/7650), and only 5 out of 10 were detected at all: It was notable that the 5 detected were those originally identified only in subjects either lacking DD or with only mild DD. The remaining 5 were originally identified in subjects with pronounced DD [10], raising the possibility that they were not detected because subjects carrying them tended not to be recruited to our cohorts.