Chunk #19 — Discussion

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Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis.

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Obesity and exogenous HFD are major risk factors for NAFLD development [1,10,11]. Thus, we used solid HFD (60% energy-derived from fat) to simulate the human conditions [10].