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Chunk #53 — Limitations

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The CHRNA5/A3/B4 gene cluster and tobacco, alcohol, cannabis, inhalants and other substance use initiation: replication and new findings using mixture analyses.
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The issue of multiple testing equally deserves consideration. We fitted a number of different models, and the effects of the ten SNPs were tested simultaneously in each model. Our correction for multiple testing was based on testing ten correlated SNPs, and did not take into account the different fitted models. The exact testing burden for an analysis that consists of fitting multiple different models has not been studied in detail, but is going to be addressed in the future.