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Chunk #25 — Results — Enrichment of brain cisSNPs in the AD GWAS from ADGC

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Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants.
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eGWAS of combined samples. About 7–10% of the transcripts could only be identified in just ADs or non–ADs, but not the combined eGWAS. Amongst such unique transcripts were CLU and BIN1, which reside at the LOAD GWAS loci [39], [40], [48] and associate with cisSNPs in the cerebellum of non–ADs. Detailed analyses of the CLU locus cisSNP/transcript associations are in-press [49].