paperKB
coga / coga-kb
Processing
Help
Sign in

Chunk #46 — Results — Latent class analysis — Genetic effect in the three and four class models

Source
The CHRNA5/A3/B4 gene cluster and tobacco, alcohol, cannabis, inhalants and other substance use initiation: replication and new findings using mixture analyses.
Embedded
yes

Text

In the 3-class model, several of the estimated regressions of class differences on the ten SNPs had p values <0.1, however only rs11637630 was marginally significant after correction for multiple testing (early vs. medium onset, p value 0.011). In the 4-class model rs8040868 differentiated early and medium onset from late onset (p values 0.007 and 0.017). This SNP had a p value of 0.027 in the 3-class model (early vs. late onset). Rs11637630 significantly predicted differences between early and later onset (p value 0.006). Rs684513 was marginally significant in differentiating early from late onset (p value 0.017).