For the GWAS sample, a total of 1,064 theta ERO measurements were recorded (with ±4 SD outliers excluded from genome-wide association analysis), corresponding to 640 cases with alcohol dependence and 424 controls, ranging in age from 17 to 69 years, and consisting of 570 males and 494 females (see Table I). Of the cases, 242 were selected from densely affected families that have been studied in previous COGA family-based linkage and association analyses, but none of these were included in the family-based replication study.
