on nicotine, and CYP2B6 and CYP2D6, which catalyze the dealkylation of aromatic ethers56, 57. In radiotracer imaging studies it is imperative that brain uptake is corrected for radiotracer metabolism, since differences in metabolism of the radiotracer determine how much radiotracer is available to the brain, e.g., fast metabolizers will have less radiotracer available to brain, while slow metabolizers will have more radiotracer available to brain for a given dose. By using the outcome measure VT/fP, we correct for individual differences in radiotracer metabolism and protein binding.
