identify whether changes in mRNA expression directly lead to changes in NMDA receptor activity. Post-translational effects of alcohol on NMDA receptors have also been reported. Fyn kinase-mediated phosphorylation of tyrosine residues on the long intracellular tail of the NR2B subunit is stimulated by acute alcohol exposure and is thought to contribute to the development of acute tolerance to the inhibitory effects of alcohol on the NMDA receptor (Yaka et al., 2003, Miyakawa et al., 1997). Finally, although our pilot study has focused on an examination of the effects of alcohol on the expression of NMDA receptor genes, study of other neurotransmitter systems, including GABAA, in iPS derived neurons will also be important.
