asthma,36 which is reported to occur at higher rates in children with ADHD,37 and RLS patients have been shown to have increased use of asthma medications.38 Studies of the PTPRD gene in mice show high expression in the hippocampus, the only brain region reported to be enlarged in ADHD,39 along with involvement in spatial learning, long-term potentiation and axonal guidance of motor neurons.40, 41, 42