Chunk #71 — Results and Discussion — FAAH gene variation modulates human amygdala habituation to threat

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Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity.

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demonstrating significantly greater habituation compared with C385 homozygotes in all three clusters (right dorsal: t-test: t(79) = 2.15, P<0.05; right ventral: t(79) = 3.15, P<0.01; left: t-test: t(79) = 2.26, P<0.05). While C385A genotype has previously been associated with human amygdala reactivity,46 these data show for the first time that FAAH variation modulates the ability of the amygdala to adapt to threat.