and together they form an interlinked network with the Long-Term Potentiation pathway at the center of these interactions. In animal studies, nicotine alters long-term potentiation585960 and learning and memory61. In humans, smoking may alleviate cognitive impairment62, and both nicotine withdrawal and schizophrenia are associated with cognitive impairments6364. Thus, compensating cognitive impairments may be a common motivational factor between regular smokers and schizophrenia patients.
