Advances in next-generation sequencing platforms have reshaped the landscape of functional genomic and epigenomic research as well as human genetics studies. Annotation of non-coding regions in the genome with genomic and epigenomic data has allowed for new testable hypotheses regarding the functional consequences of genetic variants associated with human complex traits1,2. Large consortiums such as NIH Roadmap Epigenomics3 and ENCODE4 have generated tens of thousands of sequencing-based genome-wide datasets, creating a powerful resource for the scientific community5. The WashU EpiGenome Browser6–8 continues to provide a platform for investigators to effectively engage with this resource in the context of analyzing investigators’ own data.
