Data are expressed as means ± standard error of mean (SEM). Statistical analysis was performed using GraphPad Prism6. Data distribution and normality was assayed using the Shapiro-Wilk or D'Agostino & Pearson omnibus normality tests. The Student two-tailed t-test (one sample or two-sample) or two-tailed Mann Whitney test was used for statistical comparison between two groups (based on normality) and ANOVA with Newman-Keuls Multiple Comparison Test was used for comparisons between more than two groups. Two-way ANOVA was used to estimate the effects of diagnosis and developmental stage in iPSC-generated neurons as well as quantify Western blot experiments. Post hoc comparisons between two means were conducted using the Bonferroni correction. The Spearman or Pearson correlation coefficients (based on normality) were applied for comparing correlations in post-mortem data in which one BD sample was excluded as outlier based on Grubb’s test in miR-34a, two controls and one bipolar sample were excluded for very low normalizer expression for ANK3 and CACNB3 measurements. Student t-test for unpaired data with equal variance was applied for the Sholl analyses. In order to assess if there was
