In summary, CYP2E1, which appears to be involved in fat accumulation in NAFLD, plays an important role in the advancement of steatotic livers to inflammatory NASH and IR development. This can be possibly explained by the fact that up-regulation of CYP2E1 leads to increased production of ROS/RNS, which likely increase lipid peroxidation, protein nitration, oxidation, glycation, with inflammation and the IR development, all of which can negatively affect the vital functions of the hepatocytes and ultimately lead to the development of NASH.
