present results show that alcohol-exposed 3xTg-AD mice have deficits in spatial memory (Fig. 5A) and sensorimotor gating (PPI, Fig. 5B), which are both modulated by hippocampal activity. It is also interesting to note that there was no difference in pTau (Ser199/202) IR in the BLA suggesting that apparent emotional dysregulation shown here in fear conditioning (Fig. 5C) is not related to pTau (Ser199/202) pathology. Elucidating the impact of alcohol use on Tau phosphorylation in the hippocampus has potential to move the field forward in understanding behavioral pathologies that occur in older individuals and may recommend therapeutic strategies for alleviation of specific cognitive deficits in patients with a history of alcohol use.
