The WGCNA package contains a comprehensive set of functions for performing a correlation network analysis of large, high-dimensional data sets. Functions in the WGCNA package can be divided into the following categories: 1. network construction; 2. module detection; 3. module and gene selection; 4. calculations of topological properties; 5. data simulation; 6. visualization; 7. interfacing with external software packages. An exhaustive list of implemented functions together with detailed descriptions is provided in the R package manual posted on our web site. Here we briefly outline the main functionality of the package and highlight new contributions.