Chunk #33 — Conclusion

Source

MicroRNAs and Drug Addiction.

Embedded

yes

Text

Taken together, these studies highlight the fact that miR-212 plays a critical role in fine-tuning transcriptional and neuroplastic responses to drugs of abuse. Specifically, we found that miR-212 can control cocaine intake through two complementary mechanisms: amplifying CREB signaling and reducing MeCP2/BDNF transmission in striatum.