The present article represents a first and preliminary step. We have conducted here a variety of obvious initial analyses but much remains to be done with the data available here, by us and by external investigators interested in working with these data. The present sequencing study is ongoing. We are expanding our sample: increasing the number of sequencing reads for a large minority of individuals, refining genotype calls, and extending variant calling to indels, structural variants, and the sex chromosomes. Structural variants and indels have been implicated in autism (Glessner et al., 2009) and schizophrenia (Rees et al., 2014), and represent an additional source of genetic variation of potential value. Plans are also underway to evaluate naturally occurring knockouts (e.g., stop-gains) in great detail in individuals who are homozygous, heterozygous, or compound heterozygous. Indeed, even in the present study with 1,325 sequences there were 54 stop-gain variants (almost entirely rare) in 195 autosomal candidate genes identified by the NIDA Center for Genetic Studies discussed elsewhere in this special issue (https://zork5.wustl.edu/nida/neurosnp.html). Finally, we will leverage the whole genome sequences to conduct
