To understand the specificity of the depression PWAS results, we performed a PWAS for neuroticism, body mass index (BMI), and waist-to-hip ratio adjusting for BMI (WHRadjBMI). These traits were chosen because they have a range of estimated genetic correlations with depression – 0.7 for neuroticism, 0.09 for BMI, and 0.12 for WHR26. Thus, we expected that traits with evidence of higher genetic correlation would have more PWAS results in common. We used the GWAS results for neuroticism (N=390,278)27, BMI (N=681,275)28, and WHRadjBMI (N=694,649)29 from studies examining individuals of European descent and the discovery proteomic profiles (n=376) to perform a PWAS for each trait. Using FUSION, the PWAS of neuroticism identified 72 genes, of BMI identified 395 genes, and of WHRadjBMI identified 244 genes at FDR q<0.05 (Supplementary Tables 7–9). Next, as was done for the analysis of depression, we applied SMR and HEIDI on the PWAS significant genes to remove genes with SMR p ≥ 0.05, HEIDI p ≤ 0.05, or in cases where HEIDI p was unable to be determined. The goal of these additional tests is to focus
