In smoking-stratified analyses of the association of alcohol consumption with pancreatic cancer among men, most estimates were based on a small number of exposed individuals and were imprecise with wide confidence intervals that included unity with few exceptions (Tables 4, 5). In general, risk of pancreatic cancer was greatest in the highest alcohol consumption-related categories regardless of smoking status. However, results from multivariable analyses suggested that heavy drinkers and the heaviest binge drinkers who were current smokers may be at greater risk of pancreatic cancer than former/never smokers (Table 5, binge drinking >10 years OR = 9.5, 95% CI = 1.8–50, p-trend = 0.01; ≥15 drinks/day during binge drinking OR = 9.5, 95% CI = 1.4–64, p-trend = 0.01; >35 drinks/week during the past 20 years OR = 4.2, 95% CI = 1.6–12, p-trend = 0.002, p-interaction between heavy drinking and smoking status >0.30).
