New methods are being developed that will allow researchers to analyze data concurrently, as applied in plant [138] and mouse model [139] studies. In an early adaptation of this approach in humans [140], the Two-Way Orthogonal Partial Least Squares (O2PLS) method to RNA expression and metabolomics data in 466 Finnish participants recapitulated signals detected in sequential analyses of the two data types and detected new signals by modeling the data types together. Colocalization (COLOC) [141] also enables concurrent integrative analyses. Comparisons of these and other methods will be needed to establish standard analytic practices.
