prior study has also explored the interaction between stress and CNR1 in the etiology of mood-related conditions - Juhasz et al23 found that a CNR1 haplotype, including rs1049353, was associated with neuroticism, agreeableness, and depressive symptoms. Exposure to recent negative life events interacted with rs7766029 – relative to carriers of the T allele, carriers of the CC genotype did not show an appreciable increase in vulnerability to depressive symptoms, even upon recent exposure to life events. Evidence for an interaction with rs1049353 was noted but not considered to be significant upon correction for multiple testing. The authors also reported a strong mediating influence of childhood adversity but interactions with it remained unexplored. Our study extends these prior efforts, via use of a fairly large sample and replication, adding further support for the role of the endocannabinoid system in regulation of human mood, particularly in the context of stress adaptation.
