Chunk #115 — 5. Implications for understanding gene-brain-behavior relationships in health and disease — 5.1. Intermediate phenotypes, or “endophenotypes”
This brain-based approach to understanding genetic influences on behavior was proposed by Vogel (Vogel et al., 1979b). He suggested and implemented a research strategy that first focuses on the identification of genetic variability in brain function and then explores how this variability influences behavior. In psychiatric genetics, such intermediate brain-based phenotypes were labeled as “endophenotypes”(Gottesman and Gould, 2003).
