a potential role of MPDZ in alcoholism, though a particular role in the withdrawal syndrome was not apparent. Also, Tabakoff et al. (2009) found that an MPDZ SNP is significantly associated with alcohol consumption based on data from a WHO/ISBRA Montreal study. In some cases a QTG will be the same in mouse and man, while, in other cases, animal models may identify a relevant gene network operating in both species, within which many drugable targets may exist (Hopkins, 2008). Another procedure that may be useful in this regard is to make a direct comparison of QTL data obtained from mouse studies with those from human studies using synteny mapping. Syntenic conservation makes it possible to locate the homologous regions of the genome from mice to particular chromosomal regions in humans, and vice versa.
