The drug discovery process remains a complex challenge in which systematic data integration can help unravel new findings. Although progress has been made on improving data standards (for example through efforts such as the Global Alliance for Genomics and Health (https://www.ga4gh.org/genomic-data-toolkit/), Elixir (https://elixir-europe.org/services/tag/interoperability-and-standards), and the Gene Curation Coalition https://thegencc.org/), harmonizing different biomedical datasets still constitutes one of the key bottlenecks when it comes to interpreting the available knowledge. Several other resources including Pharos (35), Disgenet (36) or CanSAR (37) have recently approached the target prioritisation problem, providing a complementary view given their respective areas of expertise (38). The Open Targets Platform aims to help address this challenge by providing users with an up-to-date systematic interpretation of the relevant resources across therapeutic areas and—ultimately—complete the knowledge-gap with data generated within the Open Targets consortium.
