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Chunk #44 — Methods — Trait Ascertainment

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Identification of 15 genetic loci associated with risk of major depression in individuals of European descent.
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The logic for composing the depression phenotype in this way was based on several considerations. For most participants (>95%), we have either just one response, or the available responses are all in agreement, so a deeper analysis of the mismatch data was unlikely to substantially affect downstream results. Our strategy of selecting one response per participant without regard for their other responses also seemed least likely to introduce bias in classification of participants who provided multiple responses.