chain–associated protein kinase 70-kDa (ZAP-70) is an integral part of the adaptive immune system because it initiates signaling at the immunological synapse between a T cell and an antigen-presenting cell.43 Previous large-scale genetic studies have implicated the MHC region on chromosome 6,44 and most of the genes that we observe in the present study to be involved in these immune system–related pathways, such as the TAP and HLA genes, map to the MHC region. Therefore, the evidence that ties the MHC region, and by implication the immune system, to the etiology of SCZ is increasing.
