Summary statistics from European ancestry subjects in CATS, COGA-ccGWAS, COGA-fGWAS, OZALC+ and SAGE were combined to form the discovery analysis. Replication analyses were conducted in the Yale-Penn (8) sample which was the major dataset contributing to the prior study by Sherva et al (8). Yale-Penn includes a large number of AA participants; thus, results from both EA and AA subjects were separately examined. Sherva et al also included SAGE data in their discovery cohort and used CATS as a replication sample. In our analyses, only the Yale-Penn component of Sherva et al (8) was used for replication, while SAGE and CATS were part of the discovery cohort.
