was no association of ADH4 with AD (Kuo et al., 2008). A rare variant downstream of ADH4 (rs187709743) was associated with symptom count in American Indians (Peng et al., 2017). An Australian study found suggestive evidence for association of rs1800759 with lifetime maxdrinks (p = 0.0075), frequency of drinking (p = 0.0055), and total consumption (p = 0.0023), and of rs3762894 with maxdrinks during the past year (p = 0.00048) and usual number of drinks (p = 0.00078) (Macgregor et al., 2009). The evidence dropped substantially after conditioning on ADH1B*2, but some evidence for association of rs3762894 with maxdrinks remained (p = 0.004) (Macgregor et al., 2009). In Koreans, several ADH4 SNPs were significant, the best being rs3805322 (p = 2.0×10−13); however conditioning the analysis on ADH1B*2 genotype reduced all of the SNPs to not significant (p>0.23) (Park et al., 2013).
