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Chunk #7 — Introduction

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Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel.
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Our method is unique in it’s ability to phase GL data at multiple sites jointly, together with a phased scaffold at a subset of sites. Methods such as Beagle [3] and MaCH/Thunder [4] could be made to accept a scaffold of unphased genotypes, by recoding the genotypes as very sequenced variants at very high coverage. However, our two stage approach allows valuable family information to be used in phasing the scaffold.