A role for the presynaptic protein RIM1α has also been demonstrated in BLA LTDi. Specifically, LFS-LTDi and DHPG-LTDi are both absent in RIM1α −/− mice (Chevaleyre et al., 2007). Interestingly, Win 55212-2-induced LTDi is also absent in Rim1α −/− mice; instead, it yielded a reversible depression. These data implicate RIM1α as an important synaptic protein mediating long-term synaptic effects of eCBs in the BLA, and other brain regions such as the hippocampus (Chevaleyre et al., 2007).
