Our study found a lesser degree of lateralization of brain functions related to face and expression processing in women than men. Furthermore, these results emphasize the importance of considering gender as a factor in the study of brain lateralization during face processing. In this light, our data may also provide an explanation of the inconsistencies in the available literature concerning the asymmetric activity of left and right occipito-temporal cortices devoted to face perception during processing of face identity, structure, familiarity or affective content.