been proposed are that an endophenotype be continuous in nature, part of a biologically plausible etiological process, and closer to the genetic causative factors than to the disorder (Flint & Munafò, 2007). Importantly, it has been noted that an endophenotype may be developmentally-defined (e.g., evident only after a certain age or only pertaining to a specific developmental period) and may only be present in response to a laboratory challenge (Hasler, Drevets, Gould, Gottesman, & Manji, 2006).
