Analyses of RNA expression data in brain tissue identified KIF25 on chromosome 6 to be a gene of interest for SRE-T in the EA sample. The minor alleles of the associated variants in this region increased the SRE-T score, risk of AD, and expression of KIF25 in both curated brain tissue data (e.g., from GTEx) and RNA expression analysis that accounted for AD status. Due to the small sample size, there was insufficient statistical power to analyze the effects of variants stratified by cases and controls. This gene encodes a protein that belongs to the kinesin-like protein family. A region that is approximately 40 kb away from KIF25 was shown to be associated with Attention Deficit Hyperactivity Disorder (Ebejer et al., 2013). However, there are few functional studies of this gene and its exact role in alcohol-related behaviors remains unknown. Nonetheless, these results highlight the importance of KIF25 expression in LR.
