We applied multiple post-meta-analysis variant filters to ensure robustness of reported findings. To reduce artifacts arising from a small number of studies, we excluded any variant that was present in only two or fewer studies. For each variant in the meta-analysis, we calculated the effective sample size Neff=∑kNkrk2, where Nk is the sample size in study k and rk2 is the imputation quality. We removed variants with effective sample sizes < 10% of the total sample size to ensure only well-imputed variants with a modicum of power were included. We also excluded all variants with minor allele frequency less than 0.001, the lower bound of moderate imputation accuracy with the currently best available imputation reference panel41. Variants with MAF > 1% are expected to be imputed with high accuracy. Results from the application of post-meta-analysis filters are displayed in Supplementary Table 25.
