Chunk #32 — Results — Do DHS- Scores Predict Outcomes Better than GW-scores? — Are DHS SNPs Enriched for Significant G×E Effects?

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Incorporating Functional Genomic Information to Enhance Polygenic Signal and Identify Variants Involved in Gene-by-Environment Interaction for Young Adult Alcohol Problems.

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yes

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Of the top independent 1137 SNPs, 55 (4.8%) showed significant evidence for interaction (p < .05 in the interaction model). In total, 27 of the 409 DHS SNPs showed significant G×E effects (7%) compared to 28 of 728 non-DHS SNPs (4%). A chi-square test of independence indicated that DHS SNPs were overrepresented among significant G×E effects relative to expectation, χ2(1) = 3.92, p = 0.05. This indicates that gene-environment interaction effects for this particular environment were modestly enriched for DHS SNPs.