patients, which is specifically enriched for the expression of MMP963. This subset expresses the chemokine receptors CCR2 and CCR5, which respond to CCL2 and CCL4/5, respectively. CD83-deficient microglia express significantly more CCL2 and CCL5 during EAE, and we detected increased levels of Th1-related transcripts as well as Mmp9 expression in the spinal cords of CD83ΔMG mice. This provides an interesting link to human data and suggests that over-activated CD83-deficient microglia recruit distinctive pathogenic T cells, which exacerbate the disease course.
