Chunk #83 — 5. Procedures for evaluating pharmacological treatments targeting alcohol abuse and dependence — 5.9. Summary

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Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.

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positive findings in FH/Wjd rats). Inhibitors of the serotonin transporter decrease ethanol intake in HAD and P (Table 4) as well as UChB (Alvarado et al., 1990) and FH/Wjd (Overstreet et al., 2007) rats. Finally, antalarmin, a CRF1 antagonist, reduces ethanol in-take in P (Table 4) as well as FH/Wjd rats (Overstreet et al., 2007). Other CRF1 antagonists have shown no effect on, or possible increases in, ethanol intake by sP rats (Table 4).