This sample (n = 2794) was a subset of the Prospective Study Dataset (N = 3286) (37); the subset included all dataset members with genotypic data. Adolescent and young adult subjects were assessed with a structured psychiatric interview [Semi-Structured Assessment for the Genetics of Alcoholism (40)] at 2-year intervals from 2004 to 2017. All subjects aged between 12 and 21 years at baseline assessment were invited to participate. Every subject with at least 1 complete interview (73% of those invited) was included in the dataset. The average age at first interview was 16.1 years (SD = 3.3), and the average age at last interview was 23.1 years (SD = 5.0). Most subjects (87%) came from extended families with a proband in treatment for an AUD (designated family type = case); 13% were from comparison families (family type = comparison), recruited from sources such as dental clinics and motor vehicle records. Subjects in comparison families were not prescreened and may be expected to have population rates of common disorders such as AUD (2). Subjects in the dataset were included in analyses
