Figure 4D, WT AAV-hrGFP animals showed a robust preference for the displaced object indicating long-term OLM. The Baf53b+/− het mice with the control virus showed significantly impaired OLM, replicating our previous findings (Fig 2C). Wildtype animals with AAV-Baf53b also show a robust preference for the displaced object similar to wildtype animals with control virus. Critically, Baf53b+/− het mice with AAV-Baf53b show a robust preference for the displaced object that is indistinguishable from wildtype animals, demonstrating a complete rescue of long-term OLM formation (Fig 4D). These findings indicate that the memory deficits observed in the Baf53b+/− het mice (Fig 4D & 2C) are due to a role for BAF53b in regulating gene expression in the adult brain and not a consequence of BAF53b's role in development.
