different views on substance use). Such use informs an individual about his personal physiological reaction, a component of motivation. Any psychoactive substance can serve this purpose, and it does depending on availability, opportunity, peer pressure, culture, etc. These episodes, and even regular “recreational” use, however, are per se usually insufficient to cross the threshold of gross violations of norms. In some cases, however, these boundaries are overstepped—whether because of a low individual basal affect/arousal level, a high individual hedonic ceiling, peer pressure or an otherwise caused need in a larger magnitude change than regularly achievable, particularly on the background of antisociality or otherwise lowering social boundaries. The amplitude of change that is sought is then above the safety level.