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Chunk #12 — Results — Tissue expression analysis and genome-wide gene-based association study (GWGAS).

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Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions.
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GWGAS conducted in MAGMA using the MDD-META GWAS meta-analysis identified 426 significant genes after Bonferroni correction for 16,038 protein coding genes. MAGMA tissue expression analysis identified enrichment across all brain tissues and pituitary using data from GTEX v8, with the strongest findings for Brodmann area 9 (p=7.31×10−16), and no enrichment in non-neuronal tissue (Figure S1).