To facilitate the biological interpretation of our top association signal, we explored the potential relationship between rs115455482 and CHRM3 expression across ten brain tissues. We associated rs115455482 genotype with CHRM3 expression in Braineac16, where genotype and gene expression data of ten brain tissues, including occipital cortex (OCTX), frontal cortex (FCTX), temporal cortex, hippocampus (HIPP), intralobular white matter, cerebellar cortex (CRBL), thalamus (THAL), putamen (PUTM), substantia nigra (SNIG), and medulla (inferior olivary nucleus, MEDU), were obtained from 134 healthy human brains from the UK Biobank17.
