Chunk #8 — Results — 95 variants and COPD susceptibility

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Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.

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We tested association of individual variants and the 95-variant risk score with COPD exacerbations in subsets of individuals from UK Biobank, deCODE, four COPD case-control studies and two eMR studies (total 2,462 COPD exacerbation cases, 15,288 COPD non-exacerbation controls) and the Lung Health Study (100 exacerbation cases, 4,002 controls). There was no association of individual variants or genetic risk score with acute exacerbations of COPD (Supplementary Tables 12 and 13).